For any cellular structure, the most important line of defense is their cell wall. Bacterias are no different. The cell wall is the only element that helps keep toxins and antibiotics out of the bacterial cell. But this also helps scientists to research the way bacteria build the cell wall. This presents with a new target site that will help destroy the bacterial cell walls and go a long way in the quest for drugs.
A bacteria has an exoskeleton (cell wall) that gives them structure and shape and protects them from outside incursion. This is very important for the survival of the concerning organisms. This also the most obvious target for developing antibiotics, since the findings of penicillin.
Antibiotics will help kill Bacteria faster
A report published by researchers from the University of Leeds studies the exact way bacterial cell walls are made. This helped discover a new pothole in the cell wall, that can serve as a new attack target for drugs. The research focusses on a bacterial protein by the name of SurA. This helps attract all other proteins from within the cell to build the cell wall.
A Nature paper reports a new group of antibiotics with a unique approach to attacking bacteria, making it a clinical candidate in the fight against antimicrobial resistance. The drugs kill bacteria by blocking the function of the bacterial cell wall. https://t.co/KRBXrUtMfK pic.twitter.com/RUxuiW2dyj
— Nature (@nature) February 13, 2020
The researchers use multiple tools and techniques to figure out exactly how SurA determines and attracts other specific proteins towards the cell wall. The team conducts the entire experimental study on an E.Coli. But it will not cause any problems in the future. Because the process works the same for many gram-negative bacteria, which are a group of major pathogens. As a result, if the SurA protein is inhibited somehow, the bacteria will not be able to build a cell wall. This will allow the antibiotics to attack the unprotected cell and help kill the bacteria.
This will make it much easier to treat many bacterial diseases. Let us know what you think about this new antibiotic treatment process.